Neutropenic enterocolitis and multidrug-resistant bacteria colonization in lymphoma patients undergoing autologous stem cell transplantation

Introduction: There is little iterature data regarding neutropenic enterocolitis (NE) development after autologous hematopoietic cell transplantation (auto-HCT) in non-Hodgkin lymphoma (NHL) patients. The aim of this study was to determine the incidence, risk factors, and clinical outcome NE auto-HCT NHL patients with respect impact multidrug-resistant Gram-negative bacteria (MDRG) vancomycin-resistant enterococci colonization on early auto-HCT. Material methods: This retrospective single-center analysis included a total 65 who underwent BEAM (BCNU, etoposide, cytosine arabinoside, melphalan) conditioning (BEAM-auto-HCT). Results: diagnosed nine (13.8%) patients, median four days In 6/9 (66%) septic shock following diagnosed. univariate analysis, MDRG before BEAM-auto-HCT only factor significant for [odds ratio (OR) 2.4 (1.14–5.0), p = 0.027], although not confirmed multivariate analysis. Additionally, [OR 5.2 (1.9–13.9), 0.001] prior transplant 2.7 (1.0–7.0), 0.041] were independent factors development. Conclusions: Our findings suggest that presenting should be kept under careful surveillance because high severe infectious complications, including abdominal ones.